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M9650019.TXT
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1996-03-09
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Document 0019
DOCN M9650019
TI Both SU and TM env proteins are responsible for monkey cell tropism of
simian immunodeficiency virus SIV mac.
DT 9605
AU Sakuragi S; Sakuragi J; Adachi A; Institute for Virus Research, Kyoto
University, Japan.
SO Arch Virol. 1995;140(12):2255-60. Unique Identifier : AIDSLINE
MED/96140618
AB While simian immunodeficiency virus (SIV) derived from an infectious
molecular clone pMA239 is tropic and pathogenic for monkeys, the virus
derived from another infectious clone pMA142 does not replicate in
monkey cells. To determine genetic sequences responsible for this
tropism, a series of recombinant clones were constructed from pMA142 and
pMA239. The determinant in pMA239 was mapped within regions encompassing
the env gene. Viruses, which carry the 239 env gene encoding surface
and/or transmembrane proteins, were tropic for monkey cells.
DE Animal Cell Line Comparative Study Gene Products,
env/BIOSYNTHESIS/*GENETICS Genes, env Human Kinetics Macaca
Recombination, Genetic Restriction Mapping Species Specificity
Support, Non-U.S. Gov't SIV/*GROWTH & DEVELOPMENT/GENETICS/PHYSIOLOGY
Time Factors Virus Replication JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).